DOI: http://dx.doi.org/10.18203/2349-3259.ijct20162790

A review of first-in-human small molecule oncology clinical trials

Daniel Greenwood, Ian Stratford, Steven Booth

Abstract


First-in-human (FIH) oncology clinical trials are crucial to the development of small-molecule oncology candidates. However, there is a dearth of research investigating how these trials vary from one-another and therefore whether one approach may be better than another. This review aims to investigate variation of FIH trials published over the last decade with respect to four areas: publication particulars; trial design; patient particulars and drug administration and formulation.


Keywords


First-in-human, Oncology, Cancer, Clinical trials, Small molecule

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