Clinical profile and outcomes of acute kidney injury patients in an intensive care unit in India

Vivek S. Narayan Pillai, C. Joe Varghese, Christopher C. Pais, Vijay Gopal Rai, Mahabala Chakrapani

Abstract

Background: The limited epidemiological and outcome data of acute kidney injury (AKI) is available in developing countries. The current single-center study determined the clinical profile of AKI by attempting to identify the presenting symptoms, etiologies, treatment modalities, and disease prognosis in patients admitted in intensive care unit at a tertiary care center in Mangalore, India.

Methods: This retrospective study enrolled 70 AKI patients between October 2001 and October 2003, admitted at Wenlock district hospital, Mangalore, KMC hospital Attawar, Mangalore and KMC hospital, Jyothi circle, Mangalore, having a serum creatinine level greater than 1.4 mg/dl and blood urea greater than 53 mg/dl.

Results: Amongst the enrolled patients, 45.7% of patients were 40-60 years old and 49 were males with no significant (p=0.412) gender difference. The most common presenting symptom was diminished micturition present in 47.1% of patients and the most common etiology of AKI was sepsis found in 27.1% of patients with the highest (17.1%) mortality. Amongst the patients who underwent conservative treatment (n=52) the mortality rate was 42.8%, while in those who underwent hemodialysis (n=18) the mortality rate was 4.2%. The overall survival rate in the study was 52.9%.

Conclusions: The epidemiological data obtained in this study is similar to the previous studies in India with hemodialysis appearing to have better disease outcomes compared to conservative therapy.

Keywords

Acute kidney injury, Sepsis, Hemodialysis, Conservative therapy

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References

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