Platelet rich plasma or platelet rich fibrin: which is better in post extraction immediate implant placement followed by immediate loading?

Swapnil Sachan, Varun Kumar, Shruti Mehta, Deepali Sharma, Prashant Singh, Pankaj S. Kushwah, Kannu Sharma

Abstract

Background: The study aimed to compare the clinical efficacy of platelet rich plasma (PRP) and platelet rich fibrin (PRF) used with phosphosilicate putty during immediate post extraction implant placement and immediate loading.

Methods: A prospective comparative clinical study was conducted on 20 adults. Two groups were made with 10 patients in each by random selection. Each patient required tooth extraction and replacement with immediate implantation and immediate loading. In Group 1 PRP was prepared from the patient's blood, mixed with alloplastic graft, and packed in peri-implant space and similarly in Group 2 PRF was prepared from the patient's blood and mixed with alloplastic graft in peri-implant space. All the patients were evaluated for postoperative pain, soft tissue analysis, implant mobility, and crestal bone height changes were observed for up to 6 months, using paired/independent t-test, and Chi-square test.

Results: It was seen that for pain on 1st postop day Group 1 had shown superior results than Group 2 after 7 days both groups showed good soft tissue healing. No significant difference was found in both groups when seen for implant mobility. The difference in crestal bone height gain in the first 3 months of Group 2 showed a remarkable height gain than in Group 1. And at 6th month overall crestal height gain difference between both groups was non-significant.

Conclusions: The autologous PRF can present new possibilities for enhanced healing and functional recovery over PRP during immediate post extractive implantation and immediate loading.

Keywords

Immediate implants, Immediate loading, PRP, PRF

Full Text:

PDF

References

Branemark PI, Zarb G, Albrektsson T. Tissue-integrated prostheses. Osseointegration in clinical dentistry. Chicago, Berlin. Quintessence Publishing Co. 1985;11-76.

Schropp L, Isidor F. Timing of implant placement relative to tooth extraction, Journal of Oral Rehabilitation. 2008;35(1):33-43.

Hong JW, Ahn SG. Immediate placement and functional loading of implants on canine with fixed partial denture for a patient having canine protected occlusion: a case report. J Adv Prosthodont. 2012;(4):52-6.

Linkow LI and Miller RJ. Immediate Loading of Endosseous Implants Is Not New. J Oral Implantol. 2004;30(5):314-7.

Atieh MA, Payne AG, Duncun WJ, Desilva RK and Cullinan MP. Immediate placement and immediate restoration/loading of single implants for molar tooth replacement: A systemic review and meta-analysis. Int Journal of Oral and Maxillofacial Implants. 2000;25:401-5.

Chen ST, Buser D. Aesthetic outcomes following immediate and early implant placement in the anterior maxilla-a systemic review. International Journal of Oral and Maxillofacial Implants. 2014;9:186-215.

Ergun G, Egilmez F. Effect of Platelet-Rich Plasma on the Outcome of Early loaded dental implants: A 3-Year Follow-up Study. 2013;39:256-62.

Anitua E, Andia I. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91: 4-15.

Raheja A, Mehta V. Platelet Rich Plasma a breakthrough In Implant Dentistry: A Review Article. University J Dent Scie. 2015;1(2):3.

Dohan DM, Choukroun J, Diss A, Dolan SL, Dohan A, Mouhije J et al. Platelet Rich Fibrin (PRF): A second generation platelet concentrate. Part –I: Technological concept and evolution. OOOOE. 2006;101:37-44.

Simonpier A. Current knowledge and perspective use of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) in oral and maxillofacial surgery Part 2: Bone graft, Implant and Reconstructive surgery. Curr Pharma Biotechnol. 2012;13:1231-56.

Yelamali T, Saikrishna T. Role of Platelet Rich Fibrin and Platelet Rich Plasma in Wound Healing of Extracted Third Molar Sockets: A Comparative Study. J. Maxillofacial Oral Surg. 2014;10(2):30-6.

Jo CH, Roh YH, Kim JE, Shin S, Yoon KS. Optimizing Platelet-Rich Plasma gel formation by varying time and gravitational forces during centrifugation. Journal of Oral Implantology. 2013;39:525-32.

Schwartz-Arad D, Grossman Y, Chaushu G. The clinical effectiveness of implants placed immediately into fresh extraction sites of molar teeth. J Periodontol. 2000;71(5):839-44.

Adell R, Lekholm U, Rockler B. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg. 1981;10(6):387-416.

AlbrektssonT, Zarb GA. Current interpretations of the osseointegrated response: clinical significance. The Int J Prostho. 1993;6:2:95-105.

Duyck J, Vandamme K. The effect of loading on peri-implant bone: a critical review of the literature” J Oral Rehabil. 2011; 38:286-94.

Avvanzo P, Ciavarella D, Avvanzo A, Giannone N, Carella M, Muzio L. Immediate placement and temporization of implants: three- to five-year retrospective results. J Oral Implantol. 2009;35(3):136-42.

Jones JR. Review of bioactive glass: From Hench to hybrids. Acta Biomaterialia. 2013;9:4457-86.

Alves R, Grimalt R. A randomized placebo-controlled, half head study to assess the efficacy of PRP on the treatment of androgenic alopecia. Dermatol Surg. 2016;42:491-7.

Marx RE. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP?.2001;10(4):225-8.

Su CY, Kuo YP, Tseng YH, Su CH. In vitro release of growth factors from platelet-rich fibrin (PRF): a proposal to optimize the clinical applications of PRF. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(2):175-9.

Khiste SV, Tari RN. Platelet-Rich Fibrin as a biofuel for tissue regeneration. ISRN Biomaterials. 2013;39:259-62.

Szmukler S, Salama H. Timing of loading and effect of micromotion on bone–dental implant Interface: Review of experimental literature. J Biomed Mater Res. 1998;(43):192-203.

Kawamura M, Urist MR. Human fibrin is a physiologic delivery system for bone morphogenetic protein. Clin Orthop Relat Res. 1988;302-10.

Kundu R, Rathee M. Effect of Platelet-Rich-Plasma (PRP) and implant surface topography on implant stability and bone. J Clin Diagn Res. 2014;8(6):ZC26-30.

Georgakopoulos I, Tsantis S. The impact of platelet-rich plasma (PRP) in osseointegration of oral implants in dental panoramic radiography. Clin Cases Miner bone Metab. 2014;11(1):59-66.

ArRejaie A, Al- Harbi F, Alagl AS, Hassan KS. Platelet-Rich Plasma gel combined with bovine-derived xenograft for the treatment of dehiscence around immediately placed conventionally loaded dental implants in humans: cone beam computed tomography and three-dimensional image evaluation. Int J Oral Maxillofac Imp. 2016;31(2):34-42.